Dynamic changes in the RNA-protein interactome during stress, development and disease
Supervisors: David Tollervey, Tony Ly
Functional interactions between RNAs and proteins underpin gene expression and defects in RNA-protein interactions form the basis of numerous human diseases. RNA binding proteins have important functions at all steps in gene expression, including transcription, RNA processing and mRNA translation, as well as in viral defence mechanisms.
Growing on the edge: The genomic basis of coastal adaptation in eyebrights (Euphrasia)
Genetic improvement for small holder dairy cattle systems in Senegal (CASE)
Supervisors: Professor John Hickey, Karen Marshall
We are offering a fully funded PhD studentship to research key questions that will underpin the establishment of a genetic improvement program for small holder dairy cattle systems in Senegal.
Repurposing ferric binding proteins for asymmetric organic synthesis: bringing proteins to life
Delivery of Raman active nanoparticles to dopaminergic neurons to investigate age-related protein aggregation
Supervisors: Prof. Alison Hulme, Dr Tilo Kunath, Dr Mathew Horrocks
This project will investigate age-associated protein aggregation within neurons using Raman active ‘loaded’ nanoparticles delivered both to human dopaminergic neurons in culture, and into the brain of a genetic rat model that has α-synuclein aggregation.