Bioscience for Health

Understanding the role of post-translational modification in age-related protein aggregation

Supervisors: David Clarke, Tilo Kunath

Project description:

This project will apply state-of-the-art-techniques in protein mass spectrometry to study the structure and function of the amyloid-forming protein alpha-synuclein. The overall aim is to understand the molecular mechanisms which lead to misfolding and aggregation in amyloid forming proteins.

Other: 

Epigenetic change with Age and Diet

Supervisors: Tom Little, Amy Buck

Project description:

Why do we age? One answer lies with epigenetic modifications, the biochemical marks and signals on DNA that change the way genes and cells operate. With age these marks get misplaced, causing degeneration. Different individuals appear to suffer such degeneration in different ways, and by understanding what causes this we can shed light upon how and why we age.  

Other: 

Delivery of Raman active nanoparticles to dopaminergic neurons to investigate age-related protein aggregation

Supervisors: Alison Hulme, Tilo Kunath

Project description:

This project will investigate age-associated protein aggregation within neurons using Raman active ‘loaded’ nanoparticles delivered both to human dopaminergic neurons in culture, and into the brain of a genetic rat model that has α-synuclein aggregation.

Other: 

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