Cellular and molecular investigation of the role of the ubiquitously expressed thioesterase Ppt1

Supervisors: Thomas WishartDouglas Lamont

Project Description:

Ppt1 is a thioesterase. Thioesterases like all esterases, are enzymes that split off an ester into acid and alcohol in the presence of water specifically at a thiol group. Ppt1 catabolises lipids in lysosomes which are intracellular membrane bound organelles.