Modelling foetal liver development and disruption using pluripotent stem cells

Supervisors: Prof David Hay, Dr Carsten Hansen

Project description:

The project will be based at the MRC Centre for Regenerative Medicine and supervised by Prof David Hay. The cell type employed in these studies is the foetal liver progenitor cell which can been produced at scale from pluripotent stem cells (Lucendo-Villarin et al 2017, Archives of Toxicology, BBC News - The aim of the current project is to use our automated liver screening system to model foetal exposure to endocrine disruptors used in the manufacture of plastics, namely bisphenols. Following on from these experiments we will compare bisphenol exposure to a panel of compounds which are known to be toxic to the liver. The later will be provided by Astra Zeneca as part of an ongoing collaboration. Following the initial screens and comparisons, the successful candidate will focus on the mechanistic changes that take place in foetal liver cell biology following bisphenol exposure using a range of established techniques. The proposed studentship builds on existing expertise and active academic and industrial collaborations. The candidate will ideally have a background in cell biology and tissue culture. In addition to scientific merits, the successful candidate will be expected to be a team player and contribute to ongoing collaborations.