Exploiting stem cell and gene editing technologies towards discovery of genetic variants important for muscle development and meat production (CASE)
Genetic dissection of individual health trajectories and their role in disease transmission (CASE)
Supervisors: Prof. Andrea Doeschl-Wilson, Prof. Ruth King, Dr Ricardo Pong-Wong, Prof. Jack Dekkers, William Herring (at the industry partner)
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Genome-wide identification of novel therapeutic targets for the control of bovine Staphylococcus aureus infection (CASE)
Early life predictors of long-life health and productivity in farm animals (CASE)
Exploring novel tools to combat infection using Mesenchymal Stem/Stromal cells and organoids (CASE)
Supervisors: Prof. David Gally, Dr Cristina Esteves, Dr Xavier Donadeu
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Discovering new host-pathogen interactions to develop antivirals and vaccine strategies against PRRSV (CASE)
In vivo live imaging and multi-omic analysis of pre-neoplastic cell metabolic change
What makes a brain endothelial cell special?
Supervisors: Anna Williams, Andrew Baker, Catalina Vallejos Meneses
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Cellular and molecular investigation of the role of the ubiquitously expressed thioesterase Ppt1
Supervisors: Thomas Wishart, Douglas Lamont
Project Description:
Ppt1 is a thioesterase. Thioesterases like all esterases, are enzymes that split off an ester into acid and alcohol in the presence of water specifically at a thiol group. Ppt1 catabolises lipids in lysosomes which are intracellular membrane bound organelles.
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